RobustcfDNAandCTCcollectionforliquidbiopsyandNIPT

• Maximizerecoveryof cfDNA,cells&plasmavolume
• NogDNAcontaminationordetectable DNAdamage
• HighestDNAmethylationMarkerintegrity
• Unprecedentedprotectionagainstshippingextremes

Product

LBgardBloodTubesaredirect-drawbloodcollectiontubespre-filledwithaproprietary,reagentthatstABIlizescellsandcell-freeDNA(cfDNA)inwholeblood,preservingBIOLOGicalanalytesfordownstreamapplications.LBgardBloodTubesalsopreventthereleaseofcellularcomponentsthatcaninterferewithanalysis,suchascellulargenomicDNAandproductsfromhemolysis. SamplescollectedinLBgardBloodTubes,whenstoredat4°C–37°C,arestabilizedfordownstreamcirculatingtumorDNAandcell-freeDNAapplicationsforupto14days.

EvaluationProtocol:BloodCollectionDevice

Selecttherightcollectiondeviceandpre-analyticvariabilitycanbereduced.Thewrongchoicecancauseinterference,delayproductlaunch,andevennecessitatere-validationofdevelopedtests.

Thisevaluationprotocolwillhelpyoudesignanexperimentthataccountsforreal-worldenvironmentalstressesandassesstheoverallrobustnessofperformance.Akeyerrorinselectingthecorrectdeviceisfailingtoincludeshippingtimeandtemperaturestresses.

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Data

Workflow

Figures

Figure1:PlasmaDNAconcentrationsarestabilizedinLBgardBloodTubevsStreckBCTandEDTAtubesover14days.

Figure2:StageIVcoloncancerpatientcfDNAisstabilizedinLBgardBloodTubesfor15days,andgenomicspillageisprevented,comparedtoStreckBCTs.

Figure3:RarecfDNAKRASG12DcancerallelesarepreservedinLBgardBloodTubesfor14dayscomparedtoStreckBCTsasmeasuredbyddPCR.

Figure4:NIPTcfDNApreservedinTrisomyTestRunonDA8600fromLifeTechnologies.

Figure5:CTCsandWBCsarepreservedinLBgardBloodTubes,withsuperiorrecoveryafterfourdayscomparedtoStreckBCTs.

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Specifications

LBgardBloodTubes,CE

• Pre-fillvolume(preservative)=0.6mL
• Blooddrawvolume=8.5mL
• Pre-fillstoragetemperature=4°C–25°C
• Post-fillstoragetemperatureforcfDNA=14daysat4°C–37°C
• Post-fillstoragetemperatureforCTCsandWBCs=4daysat18°C–30°C
• ForExportOnly.NotforsaleintheU.S.

LBgardBloodTubes

• Pre-fillvolume(preservative)=0.6mL
• Blooddrawvolume=8.5mL
• Pre-fillstoragetemperature=4°C–25°C
• Post-fillstoragetemperatureforcfDNA=14daysat4°C–37°C
• Post-fillstoragetemperatureforCTCsandWBCs=4daysat18°C–30°C
• ForResearchUseOnly.Notforuseindiagnosticprocedures.

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